A system for gathering biological material in a biological cavity comprising a catheter having a first lumen, a balloon, and a second lumen in fluid communication with said balloon. The balloon has a textured outer surface for collecting biological material. At least one device for sampling a bodily tissue, such as a needle, optic or forceps, is disposed in the first lumen. A fluid source in fluid communication with the balloon supplies fluid to the second lumen to inflate the balloon such that the textured outer surface collects additional biological material. The system is particularly useful for collecting samples in the lungs or bronchial airways, such as at a bronchial junction.