Invention Grant
- Patent Title: Anti MIF antibodies
- Patent Title (中): 抗MIF抗体
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Application No.: US12767635Application Date: 2010-04-26
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Publication No.: US08668909B2Publication Date: 2014-03-11
- Inventor: Randolf Kerschbaumer , Friedrich Scheiflinger , Manfred Rieger , Michael Thiele , Geert C. Mudde , Juergen Muellberg , Rene Hoet
- Applicant: Randolf Kerschbaumer , Friedrich Scheiflinger , Manfred Rieger , Michael Thiele , Geert C. Mudde , Juergen Muellberg , Rene Hoet
- Applicant Address: US IL Deerfield CH Glattpark (Opfikon) US MA Cambridge
- Assignee: Baxter International Inc.,Baxter Healthcare S.A.,Dyax Corp.
- Current Assignee: Baxter International Inc.,Baxter Healthcare S.A.,Dyax Corp.
- Current Assignee Address: US IL Deerfield CH Glattpark (Opfikon) US MA Cambridge
- Agency: Morgan, Lewis & Bockius LLP
- Main IPC: A61K39/395
- IPC: A61K39/395 ; C12N15/00 ; C12N5/07 ; C07K16/00
Abstract:
The present invention relates to monoclonal antibodies and antigen-binding portions thereof that specifically bind to the C-terminal or the center region of macrophage migration inhibitory factor (MIF). These anti-MIF antibodies and antigen-binding portions thereof further inhibit human MIF biological function. The invention also relates to isolated heavy and light chain immunoglobulins derived from anti-MIF antibodies and nucleic acid molecules encoding such immunoglobulins. The present invention also relates to a method of identifying anti-MIF antibodies, pharmaceutical compositions comprising these antibodies and a method of using these antibodies and compositions for the treatment of MIF-related conditions.
Public/Granted literature
- US20100260768A1 ANTI MIF ANTIBODIES Public/Granted day:2010-10-14
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