Invention Grant
US08669080B2 Mutated D-aminotransferase and method for producing optically active glutamic acid derivatives using the same
失效
突变的D-氨基转移酶及其制备使用其的光学活性谷氨酸衍生物的方法
- Patent Title: Mutated D-aminotransferase and method for producing optically active glutamic acid derivatives using the same
- Patent Title (中): 突变的D-氨基转移酶及其制备使用其的光学活性谷氨酸衍生物的方法
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Application No.: US12055605Application Date: 2008-03-26
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Publication No.: US08669080B2Publication Date: 2014-03-11
- Inventor: Masakazu Sugiyama , Kunihiko Watanabe , Tatsuki Kashiwagi , Ei-ichiro Suzuki
- Applicant: Masakazu Sugiyama , Kunihiko Watanabe , Tatsuki Kashiwagi , Ei-ichiro Suzuki
- Applicant Address: JP Tokyo
- Assignee: Ajinomoto Co., Inc.
- Current Assignee: Ajinomoto Co., Inc.
- Current Assignee Address: JP Tokyo
- Agency: Oblon, Spivak, McClelland, Maier & Neustadt, L.L.P.
- Priority: JP2002-357043 20021209; JP2003-183290 20030626
- Main IPC: C12P13/14
- IPC: C12P13/14 ; C12P21/06 ; C12N1/21 ; C07H21/04
Abstract:
A D-aminotransferase can be modified so as to efficiently produce (2R,4R)-monatin having high sweetness intensity from 4-(indol-3-ylmethyl)-4-hydroxy-2-oxoglutaric acid by mutating the amino acid sequence of a wild-type D-aminotransferase represented in SEQ ID NO:4.
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