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US08669232B2 Flavonol compounds, a bioactive extract/fraction from Ulmus wallichiana and its compounds for prevention for treatment of osteo-health related disorders 有权
黄酮醇化合物，来自榆树的生物活性提取物/部分及其用于治疗骨骼健康相关疾病的化合物

Flavonol compounds, a bioactive extract/fraction from Ulmus wallichiana and its compounds for prevention for treatment of osteo-health related disorders
Abstract:
The present invention provides a flavonol compound and a bioactive extract/fraction from Ulmus wallichiana useful for the management or prevention or treatment of bone disorders. Said extract/fraction comprising marker compounds of general formula 2, K058: R1═R2═OH K012: R1═R2═OH, 2,3 double bond K068: R1═R2═H KIOOi R1═OH, R2═H mula 2 Wherein the marker compounds K012, K058, K068, K1OO ranges 6.7-12%, 1.7-4.5%, 0.6-1.2%, 1.7-4.5% respectively in alcoholic extract and a process of extraction thereof. According to another aspect of the invention provides a pharmaceutical composition comprising the said compound. The present invention further provides a method of treating bone disorders by administering the pharmaceutical composition by oral, intravenous, subcutaneous, intra-peritoneal or intramuscular route.
Abstract(Chinese):

本发明提供了一种黄酮醇化合物和可用于治疗或预防或治疗骨骼疾病的来自榆树的生物活性提取物/部分。 所述提取物/级分包含通式2的标记化合物，K058：R1 = R2 = OHK012：R1 = R2 = OH，2,3双键K068：R1 = R2 = H KIOOi R1 = OH，R2 = Hmula 2其中 标记化合物K012，K058，K068，K100分别在酒精提取物中分别为6.7-12％，1.7-4.5％，0.6-1.2％，1.7-4.5％及其提取方法。 根据本发明的另一方面，提供了包含所述化合物的药物组合物。 本发明还提供了通过口服，静脉内，皮下，腹膜内或肌肉内途径施用药物组合物来治疗骨病的方法。

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