Invention Grant
US08669250B2 Derivatives of aryl-{4-halogeno-4-[aminomethyl]-piperidin-1-yl}-methanone, their method of preparation and their use as medicinal products
有权
芳基 - {4-卤代-4- [氨基甲基] - 哌啶-1-基} - 甲酮的衍生物，其制备方法及其作为药用物质的用途
![Derivatives of aryl-{4-halogeno-4-[aminomethyl]-piperidin-1-yl}-methanone, their method of preparation and their use as medicinal products](/docs/US/2014-03-11/US08669250B2/abs.jpg.600x600.jpg)
- Patent Title: Derivatives of aryl-{4-halogeno-4-[aminomethyl]-piperidin-1-yl}-methanone, their method of preparation and their use as medicinal products
- Patent Title (中): 芳基 - {4-卤代-4- [氨基甲基] - 哌啶-1-基} - 甲酮的衍生物，其制备方法及其作为药用物质的用途
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Application No.: US13376331Application Date: 2010-06-03
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Publication No.: US08669250B2Publication Date: 2014-03-11
- Inventor: Bernard Vacher , Francis Colpaert , Jean-Louis Maurel
- Applicant: Bernard Vacher , Francis Colpaert , Jean-Louis Maurel
- Applicant Address: FR Boulogne-Billancourt
- Assignee: Pierre Fabre Medicament
- Current Assignee: Pierre Fabre Medicament
- Current Assignee Address: FR Boulogne-Billancourt
- Agency: Birch, Stewart, Kolasch & Birch, LLP
- Priority: FR0953725 20090605
- International Application: PCT/EP2010/057781 WO 20100603
- International Announcement: WO2010/139758 WO 20101209
- Main IPC: C07D265/36
- IPC: C07D265/36 ; C07D413/12 ; A61K31/538
![Derivatives of aryl-{4-halogeno-4-[aminomethyl]-piperidin-1-yl}-methanone, their method of preparation and their use as medicinal products](/abs-image/US/2014/03/11/US08669250B2/abs.jpg.150x150.jpg)
Abstract:
The present invention concerns compounds of general formula (1) (I) wherein R1 is: —a hydrogen atom, or a halogen, —a straight or branched C1-C6 alkyl group or a C1-C3 fluoroalkyl group, —a straight or branched C1-C6 alcoxy group, a carbamyl group, N-substituted or not by one or two, straight or branched C1-C3 alkyl groups, or —a cyano group (CN) R2 is: —a hydrogen atom or a straight or branched C1-C6 alkyl group, HaI1, Hal2 and Hal3 are: —a halogen their addition salts and the hydrates of addition salts with pharmaceutically acceptable mineral acids or organic acids, and their enantiomer forms.
Public/Granted literature
- US20120115860A1 NOVEL DERIVATIVES OF ARYL--METHANONE, THEIR METHOD OF PREPARATION AND THEIR USE AS MEDICINAL PRODUCTS Public/Granted day:2012-05-10
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