Invention Grant
- Patent Title: Prolylcarboxypeptidase inhibitors
- Patent Title (中): 脯氨酰羧肽酶抑制剂
-
Application No.: US13642584Application Date: 2011-05-12
-
Publication No.: US08669252B2Publication Date: 2014-03-11
- Inventor: Dong-Ming Shen , John S. Debenham , Thomas H. Graham , Matthew J. Clements , Yong Zhang
- Applicant: Dong-Ming Shen , John S. Debenham , Thomas H. Graham , Matthew J. Clements , Yong Zhang
- Applicant Address: US NJ Rahway
- Assignee: Merck Sharp & Dohme Corp.
- Current Assignee: Merck Sharp & Dohme Corp.
- Current Assignee Address: US NJ Rahway
- Agent Baerbel R. Brown; Catherine D. Fitch
- International Application: PCT/US2011/036161 WO 20110512
- International Announcement: WO2011/146300 WO 20111124
- Main IPC: A61K31/535
- IPC: A61K31/535 ; A61K31/445 ; A61K31/40 ; A61K31/415 ; C07D295/18 ; C07D413/12 ; C07D211/30 ; C07D207/06 ; C07D233/61 ; C07D205/04
Abstract:
Compounds of structural formula I are inhibitors of prolylcarboxypeptidase (PrCP). The compounds of the present invention are useful for the prevention and treatment of conditions related to the enzymatic activity of PrCP such as abnormal metabolism, including obesity; diabetes; metabolic syndrome; obesity related disorders; and diabetes related disorders.
Public/Granted literature
- US20130217660A1 NOVEL PROLYLCARBOXYPEPTIDASE INHIBITORS Public/Granted day:2013-08-22
Information query
