Invention Grant
US08669260B2 Ketoconazole-derivative antagonist of human pregnane X receptor and uses thereof
有权
人类孕烷X受体的酮康唑衍生物拮抗剂及其用途
- Patent Title: Ketoconazole-derivative antagonist of human pregnane X receptor and uses thereof
- Patent Title (中): 人类孕烷X受体的酮康唑衍生物拮抗剂及其用途
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Application No.: US12735368Application Date: 2009-01-27
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Publication No.: US08669260B2Publication Date: 2014-03-11
- Inventor: Sridhar Mani , Bhaskar C. Das
- Applicant: Sridhar Mani , Bhaskar C. Das
- Applicant Address: US NY Bronx
- Assignee: Albert Einstein College of Medicine of Yeshiva University
- Current Assignee: Albert Einstein College of Medicine of Yeshiva University
- Current Assignee Address: US NY Bronx
- Agency: Amster, Rothstein & Ebenstein LLP
- International Application: PCT/US2009/000524 WO 20090127
- International Announcement: WO2009/110955 WO 20090911
- Main IPC: A61K31/496
- IPC: A61K31/496 ; C07D317/22
Abstract:
The application discloses ketoconazole derivatives that are antagonists of the human pregnane X receptor (PXR), methods of preparing the derivatives, uses of the derivatives with drug therapy, and methods of inhibiting tumor cell proliferation and multidrug resistance using inhibitors of PXR.
Public/Granted literature
- US20110105522A1 KETOCONAZOLE-DERIVATIVE ANTAGONIST OF HUMAN PREGNANE X RECEPTOR AND USES THEREOF Public/Granted day:2011-05-05
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