Invention Grant
US08669261B2 Acrylomido derivatives useful as inhibitors of the mitochondrial permeability transition
有权
Acrylomido衍生物可用作线粒体通透性转换的抑制剂
- Patent Title: Acrylomido derivatives useful as inhibitors of the mitochondrial permeability transition
- Patent Title (中): Acrylomido衍生物可用作线粒体通透性转换的抑制剂
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Application No.: US13874081Application Date: 2013-04-30
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Publication No.: US08669261B2Publication Date: 2014-03-11
- Inventor: Daniele Fancelli , Mario Varasi , Simon Plyte , Marco Ballarini , Anna Cappa , Giacomo Carenzi , Saverio Minucci , Gilles Pain , Manuela Villa
- Applicant: Daniele Fancelli , Mario Varasi , Simon Plyte , Marco Ballarini , Anna Cappa , Giacomo Carenzi , Saverio Minucci , Gilles Pain , Manuela Villa
- Applicant Address: IT Milan
- Assignee: Congenia SLR
- Current Assignee: Congenia SLR
- Current Assignee Address: IT Milan
- Agency: Cooper & Dunham LLP
- Agent Gary J. Gershik
- Main IPC: A61K31/4965
- IPC: A61K31/4965 ; A61K31/445 ; A61K31/4178 ; A61K31/416 ; A61K31/22 ; A61K31/19 ; A61K31/18 ; A61K31/167
Abstract:
Acrylamido derivatives useful as therapeutic agents, particularly for the prevention and/or treatment of diseases and conditions associated with the activity of the mitochondrial permeability transition pore (MPTP), such as the diseases characterized by ischemia/reperfusion, oxidative or degenerative tissue damage, are herein described. These compounds belong to the structural formula (I) wherein R, R′, R″, W and a are as defined in the specification. The invention also relates to the preparation of these compounds, as well as to pharmaceutical compositions comprising them.
Public/Granted literature
- US20130245019A1 ACRYLOMIDO DERIVATIVES USEFUL AS INHIBITORS OF THE MITOCHONDRIAL PERMEABILITY TRANSITION Public/Granted day:2013-09-19
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