Invention Grant
- Patent Title: Pharmaceutical composition comprising a bi-cyclic compound and method for stabilizing the bi-cyclic compound
- Patent Title (中): 包含双环化合物的药物组合物和用于稳定双环化合物的方法
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Application No.: US13161060Application Date: 2011-06-15
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Publication No.: US08669284B2Publication Date: 2014-03-11
- Inventor: Ryu Hirata , Yasuhiro Harada , Ryuji Ueno
- Applicant: Ryu Hirata , Yasuhiro Harada , Ryuji Ueno
- Applicant Address: CH Zug JP Tokyo
- Assignee: Sucampo AG,R-Tech Ueno, Ltd.
- Current Assignee: Sucampo AG,R-Tech Ueno, Ltd.
- Current Assignee Address: CH Zug JP Tokyo
- Agency: Sughrue Mion, PLLC
- Main IPC: A61K9/64
- IPC: A61K9/64 ; A61K31/352
Abstract:
Disclosed is a method for stabilizing a pharmaceutically active bi-cyclic compound of formula (I): comprising the step of: admixing the same with a polyol and/or a fatty acid ester other than glyceride and a composition obtained by the method. In addition a soft gelatin capsule formulation of the compound of formula (I) obtained by incorporating the compound in a soft gelatin capsule shell comprising gelatin and a polyol plasticizer.
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