Invention Grant
US08669370B2 Substituted 3-heteroaroylamino-propionic acid derivatives and their use as pharmaceuticals
有权
取代的3-杂芳酰基氨基 - 丙酸衍生物及其作为药物的用途
- Patent Title: Substituted 3-heteroaroylamino-propionic acid derivatives and their use as pharmaceuticals
- Patent Title (中): 取代的3-杂芳酰基氨基 - 丙酸衍生物及其作为药物的用途
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Application No.: US13357245Application Date: 2012-01-24
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Publication No.: US08669370B2Publication Date: 2014-03-11
- Inventor: Sven Ruf , Thorsten Sadowski , Klaus Wirth , Herman Schreuder , Christian Buning
- Applicant: Sven Ruf , Thorsten Sadowski , Klaus Wirth , Herman Schreuder , Christian Buning
- Applicant Address: FR Paris
- Assignee: SANOFI
- Current Assignee: SANOFI
- Current Assignee Address: FR Paris
- Agency: Scully, Scott, Murphy & Presser, P.C.
- Priority: EP11305078 20110126
- Main IPC: A61K31/44
- IPC: A61K31/44 ; C07D213/46
Abstract:
The present invention relates to compounds of the formula I, wherein A, D, E, L, G, R10, R30, R40, R50 and R60 have the meanings indicated in the claims, which are valuable pharmaceutical active compounds. They are inhibitors of the protease cathepsin A, and are useful for the treatment of diseases such as atherosclerosis, heart failure, renal diseases, liver diseases or inflammatory diseases, for example. The invention furthermore relates to processes for the preparation of the compounds of the formula I, their use and pharmaceutical compositions comprising them.
Public/Granted literature
- US20120252809A1 SUBSTITUTED 3-HETEROAROYLAMINO-PROPIONIC ACID DERIVATIVES AND THEIR USE AS PHARMACEUTICALS Public/Granted day:2012-10-04
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