A millimeter-wave radio frequency (RF) system, and method thereof for transferring multiple signals over a single transmission line connected between modules of a millimeter-wave RF system. The system comprises a single transmission line for connecting a first part of the RF system and a second part of the RF system, the single transmission line transfers a multiplexed signal between the first part and second part, wherein the multiplexed signal includes intermediate frequency (IF) signal, a local oscillator (LO) signal, a control signal, and a power signal; the first part includes a baseband module and a chip-to-line interface module for interfacing between the baseband module and the single transmission line; and the second part includes a RF module and a line-to-chip interface module for interfacing between the RF module and the single transmission line, wherein the first part and the second part are located away from each other.