Various embodiments are directed toward improving Virtual Machine performance by reducing the amount of communication protocol processing performed between co-resident Virtual Machine guest applications executing on the same physical machine. Overhead can be reduced by short-circuiting the full communication protocol stack when a plurality of Virtual Machine guest applications are hosted and executing on the same physical machine such as a data storage node or a compute accelerator node. Improvements may also be realized by enabling the sharing in virtual memory of physical memory pages between co-resident Virtual Machine guest applications, and employing a low latency high bandwidth network for enabling guest applications to communicate with each other that are located in different nodes in a data storage cluster.