Needleless access port valves are generally discussed herein with particular discussions extended to needleless access port valves having a pliant valve piston and/or plug that exudes silicone oil when stressed or squeezed while providing antimicrobial agents within and on the surface of the piston and/or plug. The pliant valve piston may have an integrally formed plug and one or more ports or a separately formed plug located inside a plastic housing. The plug cooperates with a nozzle on the inlet connector assembly to form a slip port or a Luer inlet, which can open when exerted by force to permit flow or closes when the force is removed.