The present disclosure provides a mirror device with illumination comprising a transparent conductive substrate, an isolation layer, a mirror layer and a light emitting diode (LED) layer. The isolation layer, formed on a surface of the transparent conductive substrate, divides the surface of the transparent conductive substrate into at least one first region and at least one second region. The mirror layer formed on the transparent conductive substrate within the at least one first region, while the LED layer is formed on the transparent conductive substrate within the at least one second region, wherein the mirror layer and the LED layer are electrically isolated from each other. In another embodiment, the present disclosure further provides a mirror box having the mirror device with illumination disposed therein so that the mirror device can be easily carried and kept in the pocket, or purse of user.