A product container holder for accommodating a product container, wherein the product container holder can be separately handled and can be inserted into an injection device, and includes an engaging member that can be moved transversely to the longitudinal axis of the product container holder and which can block a movement of the product container relative to the product container holder in the distal direction, and a securing structure which can be moved relative to the engaging member from an initial position to a securing position in which it restricts the mobility of the engaging member. In some embodiments, a method of making and a method of using the product container holder is encompassed, as is a container and an injection device with which the holder can be used.