Radio frequency transmission systems often suffer from the problem of co-site interference, where the frequency band of a strong radio transmitter overlaps with the frequency band of a co-located and/or remote radio receiver, such that the transmitter interferes with the ability of the receiver to detect a weak signal of interest. There is a need for a device that can process both the transmitted radio signal and the received radio signal to eliminate such interference. Previous attempts to solve this problem have been unable to cancel in-band interference in excess of 20 to 40 dB stronger than the signal of interest over a broad bandwidth, with large dynamic range, and with a high degree of linearity. Disclosed is a robust system and method for cancelling broadband in-band RF interference that operates in a dynamically changing multipath environment.