A ammunition loading machine is provided. The ammunition loading machine includes a base frame. A rake assembly is mounted to the base frame and configured to index a linear row of cases along a first linear axis. A platen assembly is also mounted to the base frame and is movable relative to the base frame along a second linear axis that is orthogonal to the first linear axis. A propellant hopper is fixedly mounted to the base frame. The platen assembly is movable relative to the propellant hopper to transfer propellant from the propellant hopper to a propellant filling mechanism that is movable with the platen assembly. The rake assembly is adjustable to accommodate multiple different sizes of cartridges. The rake assembly and platen assembly are commonly linked to a cam drive mechanism for simultaneously moving the rake assembly and the platen assembly.