A self-sealing valve comprises a valve housing having a fluid conduit, a valve seat, and a retaining member, the valve housing being configured to pass fluid through the fluid conduit, and a flexible diaphragm comprising a flexible material having resiliency, wherein the retaining member and the flexible diaphragm are configured so that the retaining member retains a portion of the flexible diaphragm so as to use the resiliency of the flexible material to bias the flexible diaphragm against the valve seat to a closed position of the self-sealing valve to provide a self-seal of the fluid conduit, and to facilitate movement of the flexible diaphragm under a fluid bias against a first side of the flexible diaphragm in a first direction away from the valve seat to an open position, and wherein the retaining member and the flexible diaphragm are configured so that the self-sealing valve can be contacted to move a portion of the flexible diaphragm away from the valve seat to the open position.