Invention Grant
- Patent Title: Neutralizing anti-influenza A virus antibodies and uses thereof
- Patent Title (中): 中和抗甲型流感病毒抗体及其用途
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Application No.: US12509835Application Date: 2009-07-27
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Publication No.: US08685402B2Publication Date: 2014-04-01
- Inventor: Antonio Lanzavecchia
- Applicant: Antonio Lanzavecchia
- Applicant Address: CH Bellinzona
- Assignee: Institute for Research in Biomedicine
- Current Assignee: Institute for Research in Biomedicine
- Current Assignee Address: CH Bellinzona
- Agent Dennis A. Bennett; Suman Mirmira
- Main IPC: C07K16/00
- IPC: C07K16/00 ; A61K39/42 ; C07H21/00 ; C12N5/00 ; C12N15/00

Abstract:
The invention relates to antibodies and antigen binding fragments thereof, that bind to hemagglutinin and neutralize infection of at least two different group 1 subtypes or at least two different group 2 subtypes of influenza A virus. The invention also relates to nucleic acids that encode, immortalized B cells and cultured single plasma cells that produce, and to epitopes that bind to, such antibodies and antibody fragments. In addition, the invention relates to the use of the antibodies, antibody fragments, and epitopes in screening methods as well as in the diagnosis, treatment and prevention of influenza A virus infection.
Public/Granted literature
- US20100086555A1 NEUTRALIZING ANTI-INFLUENZA A VIRUS ANTIBODIES AND USES THEREOF Public/Granted day:2010-04-08
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