Invention Grant
US08685402B2 Neutralizing anti-influenza A virus antibodies and uses thereof 有权
中和抗甲型流感病毒抗体及其用途

Neutralizing anti-influenza A virus antibodies and uses thereof
Abstract:
The invention relates to antibodies and antigen binding fragments thereof, that bind to hemagglutinin and neutralize infection of at least two different group 1 subtypes or at least two different group 2 subtypes of influenza A virus. The invention also relates to nucleic acids that encode, immortalized B cells and cultured single plasma cells that produce, and to epitopes that bind to, such antibodies and antibody fragments. In addition, the invention relates to the use of the antibodies, antibody fragments, and epitopes in screening methods as well as in the diagnosis, treatment and prevention of influenza A virus infection.
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