A natural product energy formulation is provided for a pet, which synergistically aids in (1) function of the heart, (2) energy production, such as in muscles, and/or (3) enhances removal of toxic free radicals. For example, the natural product energy formulation enhances function of the heart, by the use of CoQ10; enables the body to produce more energy through enhanced efficiency of the Krebs cycle, such as by use of L-carnitine; and aids in the removal of waste and/or toxins produced in the body, such as by providing anti-oxidants. Hence, the energy formulation synergistically optimizes the heart, muscles, and toxin removal at the same time, which allows for a more active, healthy, and/or interactive pet, where the pet can prolong duration of exercise, increase intensity of exercise, and recover faster. The natural product formulation for pets optionally contains a lipotropic constituent to aid in fat metabolism and/or weight loss.