Invention Grant
US08685681B2 Diacylglycerol acyltransferases for alteration of polyunsaturated fatty acids and oil content in oleaginous organisms
有权
用于改变多不饱和脂肪酸的二酰基甘油酰基转移酶和含油生物体中的油含量
- Patent Title: Diacylglycerol acyltransferases for alteration of polyunsaturated fatty acids and oil content in oleaginous organisms
- Patent Title (中): 用于改变多不饱和脂肪酸的二酰基甘油酰基转移酶和含油生物体中的油含量
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Application No.: US12338536Application Date: 2008-12-18
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Publication No.: US08685681B2Publication Date: 2014-04-01
- Inventor: Narendra S. Yadav , Zhixiong Xue , Hongxiang Zhang
- Applicant: Narendra S. Yadav , Zhixiong Xue , Hongxiang Zhang
- Applicant Address: US DE Wilmington
- Assignee: E I du Pont de Nemours and Company
- Current Assignee: E I du Pont de Nemours and Company
- Current Assignee Address: US DE Wilmington
- Main IPC: C12P7/64
- IPC: C12P7/64 ; C12N9/10 ; C12P21/06 ; C12N1/20 ; C12N1/16 ; C12N1/12 ; C07H21/04
Abstract:
Acyltransferases are provided, suitable for use in the manufacture of microbial oils enriched in omega fatty acids in oleaginous yeast (e.g., Yarrowia lipolytica). Specifically, genes encoding diacylglycerol acyltransferase (DGAT1) have been isolated from Y. lipolytica and Mortierella alpina. These genes encode enzymes that participate in the terminal step in oil biosynthesis in yeast. Each is expected to play a key role in altering the quantity of polyunsaturated fatty acids produced in oils of oleaginous yeasts.
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