Invention Grant
US08685920B2 Method of targeting specific cell populations using cell-binding agent maytansinoid conjugates linked via a non-cleavable linker, said conjugates and methods of making said conjugates
有权
使用通过不可切割接头连接的细胞结合剂美登木素生物碱缀合物靶向特定细胞群的方法，所述缀合物和制备所述缀合物的方法
- Patent Title: Method of targeting specific cell populations using cell-binding agent maytansinoid conjugates linked via a non-cleavable linker, said conjugates and methods of making said conjugates
- Patent Title (中): 使用通过不可切割接头连接的细胞结合剂美登木素生物碱缀合物靶向特定细胞群的方法，所述缀合物和制备所述缀合物的方法
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Application No.: US13178728Application Date: 2011-07-08
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Publication No.: US08685920B2Publication Date: 2014-04-01
- Inventor: Ravi V. J. Chari , Wayne C. Widdison
- Applicant: Ravi V. J. Chari , Wayne C. Widdison
- Applicant Address: US MA Waltham
- Assignee: Immunogen Inc.
- Current Assignee: Immunogen Inc.
- Current Assignee Address: US MA Waltham
- Agency: Sughrue Mion, PLLC
- Main IPC: C07D498/00
- IPC: C07D498/00
Abstract:
The present invention discloses a method for targeting maytansinoids to a selected cell population, the method comprising contacting a cell population or tissue suspected of containing the selected cell population with a cell-binding agent maytansinoid conjugate, wherein one or more maytansinoids is covalently linked to the cell-binding agent via a non-cleavable linker and the cell-binding agent binds to cells of the selected cell population.
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