Invention Grant
US08685921B2 Inhibitors of beta integrin-G protein alpha subunit binding interactions
有权
β整合素-G蛋白α亚基结合相互作用的抑制剂
- Patent Title: Inhibitors of beta integrin-G protein alpha subunit binding interactions
- Patent Title (中): β整合素-G蛋白α亚基结合相互作用的抑制剂
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Application No.: US13621064Application Date: 2012-09-15
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Publication No.: US08685921B2Publication Date: 2014-04-01
- Inventor: Xiaoping Du
- Applicant: Xiaoping Du
- Applicant Address: US IL Urbana
- Assignee: The Board of Trustees of the University of Illinois
- Current Assignee: The Board of Trustees of the University of Illinois
- Current Assignee Address: US IL Urbana
- Agency: Marshall, Gerstein & Borun LLP
- Main IPC: A61K38/36
- IPC: A61K38/36 ; C07K7/06 ; C07K7/08 ; A61K38/08 ; A61K38/10 ; C07K14/745 ; A61P9/00 ; A61P7/02
Abstract:
Provided herein are compounds that inhibit a binding interaction between a β integrin and a G protein subunit, as well as compositions, e.g., pharmaceutical compositions, comprising the same, and related kits. In some embodiments, the compound is an antibody or antibody analog, and, in other embodiments, the compound is a peptide or peptide analog. Also provided are methods of using the compounds, including methods of treating or preventing a medical condition, such as stroke, heart attack, cancer, or inflammation.
Public/Granted literature
- US20130072433A1 INHIBITORS OF BETA INTEGRIN-G PROTEIN ALPHA SUBUNIT BINDING INTERACTIONS Public/Granted day:2013-03-21
Information query
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