Invention Grant
- Patent Title: Fibrillar albumin for use in inhibiting cancer growth
- Patent Title (中): 用于抑制癌症生长的纤维白蛋白
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Application No.: US13572652Application Date: 2012-08-12
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Publication No.: US08685923B2Publication Date: 2014-04-01
- Inventor: Shu-Mei Liang , Chun-Yung Huang , Chi-Ming Liang
- Applicant: Shu-Mei Liang , Chun-Yung Huang , Chi-Ming Liang
- Applicant Address: TW Taipei
- Assignee: Academia Sinica
- Current Assignee: Academia Sinica
- Current Assignee Address: TW Taipei
- Agency: Intellectual Property Connections, Inc.
- Agent Hsiu-Ming Saunders
- Main IPC: A61K38/38
- IPC: A61K38/38 ; C07K14/76 ; C07K1/16

Abstract:
A method for inhibiting survival of cancer cells in a subject is disclosed. The method comprises administering to a subject in need thereof a therapeutically effective amount of fibrillar albumin. The preparation of the fibrillar albumin comprises: (i) forming a solution comprising an isolated and/or purified globular albumin; (ii) adding a detergent to the solution containing the isolated and/or purified globular albumin, wherein the detergent is one selected from the group consisting of sodium dodecyl sulfate (SDS) and n-tetradecyl-N,N-dimethyl-3-ammonio-1-propanesulfonate; (iii) applying the solution to a molecular sizing column with a pore size that permits separation of a protein with a molecular weight of at least about 70 kDa so as to promote column-induced formation of the fibrillar albumin from the isolated and/or purified globular albumin; and (iv) eluting the fibrillar albumin from the column, wherein the eluted albumin has a fibrillar structure.
Public/Granted literature
- US20120316117A1 PROCESS TO PRODUCE FIBRILLAR PROTEINS AND METHOD OF TREATMENT USING FIBRILLAR PROTEINS Public/Granted day:2012-12-13
Information query
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