Invention Grant
US08685954B2 Methods and compositions for treating cancer using proteasome inhibitors
有权
使用蛋白酶体抑制剂治疗癌症的方法和组合物
- Patent Title: Methods and compositions for treating cancer using proteasome inhibitors
- Patent Title (中): 使用蛋白酶体抑制剂治疗癌症的方法和组合物
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Application No.: US13242209Application Date: 2011-09-23
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Publication No.: US08685954B2Publication Date: 2014-04-01
- Inventor: Kenneth C. Anderson , Teru Hideshima , Constantine S. Mitsiades , Nicholas Mitsiades
- Applicant: Kenneth C. Anderson , Teru Hideshima , Constantine S. Mitsiades , Nicholas Mitsiades
- Applicant Address: US MA Boston
- Assignee: Dana-Farber Cancer Institute, Inc.
- Current Assignee: Dana-Farber Cancer Institute, Inc.
- Current Assignee Address: US MA Boston
- Agency: Foley Hoag LLP
- Main IPC: A61K38/08
- IPC: A61K38/08 ; A61K38/05 ; A61K31/04
Abstract:
The present invention relates to therapeutic compositions for treating cancer or preventing the growth of cancer cells, e.g., tumor growth, in a subject. The present invention also relates to methods for treating cancer, e.g., inhibiting tumor growth, in a subject who has become resistant to treatment, by administering to a subject an effective amount of a proteasome inhibitor and an effective amount of a therapeutic agent, e.g., a chemotherapeutic agent. The present invention further relates to methods for purging bone marrow, i.e., removing cancer cells from bone marrow, by exposing the bone marrow cells to a proteasome inhibitor and a therapeutic agent, e.g., a chemotherapeutic agent.
Public/Granted literature
- US20120214757A1 Methods and Compositions for Treating Cancer Using Proteasome Inhibitors Public/Granted day:2012-08-23
Information query
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