Invention Grant
US08685960B2 6-pyridin-3-yl-3,4-dihydro-1h-quinolin-2-one derivatives and related compounds as inhibitors of the human aldosterone synthase CYP11B2
有权
6-吡啶-3-基-3,4-二氢-1h - 喹啉-2-酮衍生物和相关化合物作为人醛固酮合酶CYP11B2的抑制剂
- Patent Title: 6-pyridin-3-yl-3,4-dihydro-1h-quinolin-2-one derivatives and related compounds as inhibitors of the human aldosterone synthase CYP11B2
- Patent Title (中): 6-吡啶-3-基-3,4-二氢-1h - 喹啉-2-酮衍生物和相关化合物作为人醛固酮合酶CYP11B2的抑制剂
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Application No.: US12990909Application Date: 2009-05-05
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Publication No.: US08685960B2Publication Date: 2014-04-01
- Inventor: Rolf W. Hartmann , Ralf Heim , Simon Lucas
- Applicant: Rolf W. Hartmann , Ralf Heim , Simon Lucas
- Applicant Address: DE
- Assignee: Elexopharm GmbH
- Current Assignee: Elexopharm GmbH
- Current Assignee Address: DE
- Agency: Riverside Law LLP
- Priority: DE102008022221 20080506
- International Application: PCT/EP2009/003217 WO 20090505
- International Announcement: WO2009/135651 WO 20091112
- Main IPC: C07D401/04
- IPC: C07D401/04 ; A61K31/4745
Abstract:
The invention provides compounds of the general formula (I) which are inhibitors of the human aldosterone synthase, and also pharmaceutical compositions containing these compounds, and the use of these compounds and other heteroaryl substituted quinolinone derivatives for the treatment of hyperaldosteronism and/or disorders or diseases that are mediated by 11 β-hydroxylase (CYP11 B1).
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