Invention Grant
- Patent Title: CGRP receptor antagonists
- Patent Title (中): CGRP受体拮抗剂
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Application No.: US13121784Application Date: 2009-09-29
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Publication No.: US08685965B2Publication Date: 2014-04-01
- Inventor: Donnette D. Staas , Ian M. Bell , Harold G. Selnick
- Applicant: Donnette D. Staas , Ian M. Bell , Harold G. Selnick
- Applicant Address: US NJ Rahway
- Assignee: Merck Sharp & Dohme Corp.
- Current Assignee: Merck Sharp & Dohme Corp.
- Current Assignee Address: US NJ Rahway
- Agent H. Eric Fischer; John C. Todaro
- International Application: PCT/US2009/058711 WO 20090929
- International Announcement: WO2010/039673 WO 20100408
- Main IPC: A61K31/537
- IPC: A61K31/537

Abstract:
Compounds of Formula (I), (wherein variables A1, A2, A3, A4, A5, A6, A7, A8, L, J, Q, R4, Ea, Eb, Ec, R6, R7, Re, Rf, RPG, W, Y and Z are as described herein) useful as antagonists of CGRP receptors, and useful in the treatment or prevention of diseases in which CGRP receptors are involved, such as headache, and in particular migraine and cluster headache. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP receptors are involved.
Public/Granted literature
- US20110224201A1 CGRP RECEPTOR ANTAGONISTS Public/Granted day:2011-09-15
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