Invention Grant
- Patent Title: Inhibition of ornithine aminotransferase for the treatment of proliferative disorders
- Patent Title (中): 抑制鸟氨酸氨基转移酶治疗增殖性疾病
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Application No.: US13484392Application Date: 2012-05-31
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Publication No.: US08686041B2Publication Date: 2014-04-01
- Inventor: Yaron Ilan , Ehud Zigmond , Richard B. Silverman , Hejun Lu
- Applicant: Yaron Ilan , Ehud Zigmond , Richard B. Silverman , Hejun Lu
- Applicant Address: IL Jerusalem US IL Evanston
- Assignee: Hadasit Medical Research Services & Development, Ltd.,Northwestern University
- Current Assignee: Hadasit Medical Research Services & Development, Ltd.,Northwestern University
- Current Assignee Address: IL Jerusalem US IL Evanston
- Agency: Roach Brown McCarthy & Gruber, P.C.
- Agent Kevin D. McCarthy
- Priority: IL177609 20060821
- Main IPC: A01N37/08
- IPC: A01N37/08 ; A01N53/00 ; A61K31/19 ; A61K31/557

Abstract:
The invention relates to inhibition of ornithine aminotransferase (OAT) for suppression of tumor cells proliferation. More particularly, the invention relates to methods of treatment of proliferative disorders by the selective inhibition of OAT, and further provides the use of OAT inhibitors, specifically, 5-amino-1,3-hexadienyl-carboxylic acid (Gabaculine), and Gabaculine analogue 8, for compositions and methods for the treatment of proliferative disorders such as hepatocellular carcinoma. The invention further provides methods and kits for the diagnosis of a pathologic proliferative disorder in a mammalian subject, based on determining the level of OAT expressed in a biological sample obtained from a subject.
Public/Granted literature
- US20120245380A1 Inhibition of Ornithine Aminotransferase for the Treatment of Proliferative Disorders Public/Granted day:2012-09-27
Information query
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