Invention Grant
US08686140B2 Method of purifying a salt, sodium salt and disodium salt of pemetrexed
有权
培美曲塞的盐，钠盐和二钠盐的纯化方法
- Patent Title: Method of purifying a salt, sodium salt and disodium salt of pemetrexed
- Patent Title (中): 培美曲塞的盐，钠盐和二钠盐的纯化方法
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Application No.: US12739576Application Date: 2008-10-21
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Publication No.: US08686140B2Publication Date: 2014-04-01
- Inventor: Jie Luo , Meng Lin , Bo Lin , Wenrun Ye , Yongmei Qin , Jie Deng
- Applicant: Jie Luo , Meng Lin , Bo Lin , Wenrun Ye , Yongmei Qin , Jie Deng
- Applicant Address: CN
- Assignee: Chongqing Pharmaceutical Research Institute Co., Ltd.
- Current Assignee: Chongqing Pharmaceutical Research Institute Co., Ltd.
- Current Assignee Address: CN
- Agency: Baker & Hostetler LLP
- Priority: CN200710092879 20071024
- International Application: PCT/CN2008/072758 WO 20081021
- International Announcement: WO2009/056029 WO 20090507
- Main IPC: C07D487/04
- IPC: C07D487/04
Abstract:
A method of purifying a salt of pemetrexed having a structure of formula (III) by salting-out, wherein if M3+ is H+, then each of M1+ and M2+ is independently H+, Li+, Na+ or K+, provided that both of them are not H+; if M3+ is Li+, Na+ or K+, then each of M1+ and M2+ is independently Li+, Na+ or K+.
Public/Granted literature
- US20100305319A1 METHOD OF PURIFYING A SALT, SODIUM SALT AND DISODIUM SALT OF PEMETREXED Public/Granted day:2010-12-02
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