Invention Grant
- Patent Title: Montelukast 4-halobenzylamine salt and method for preparing montelukast sodium salt by using the same
- Patent Title (中): 孟鲁司特4-卤苄胺盐及其使用方法制备孟鲁司特钠盐
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Application No.: US13730168Application Date: 2012-12-28
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Publication No.: US08686151B2Publication Date: 2014-04-01
- Inventor: Hyuk Chul Kwon , Man Dong Rho , Kyung Hoi Cha
- Applicant: Dong Kook Pharm. Co., Ltd.
- Applicant Address: KR Seoul
- Assignee: Dong Kook Pharm. Co., Ltd.
- Current Assignee: Dong Kook Pharm. Co., Ltd.
- Current Assignee Address: KR Seoul
- Agency: Edwards Wildman Palmer LLP
- Priority: KR10-2010-0074005 20100730
- Main IPC: C07D215/14
- IPC: C07D215/14

Abstract:
Disclosed are a novel montelukast 4-halobenzylamine salt, and a method for preparing a montelukast sodium salt by using the same. In the disclosed method, a montelukast 4-halobenzylamine salt represented by Formula 2 or a montelukast sodium salt represented by Formula 1 is prepared by obtaining a compound represented by Formula 3 from a compound represented by Formula 5, in the same reactor, without an additional obtaining process. In Formula 2, X represents F, Cl, Br or I.
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