Invention Grant
- Patent Title: Neprilysin inhibitors
- Patent Title (中): Neprilysin抑制剂
-
Application No.: US13475017Application Date: 2012-05-18
-
Publication No.: US08686184B2Publication Date: 2014-04-01
- Inventor: Melissa Fleury , Roland Gendron , Adam D. Hughes , Jane Schmidt
- Applicant: Melissa Fleury , Roland Gendron , Adam D. Hughes , Jane Schmidt
- Applicant Address: US CA South San Francisco
- Assignee: Theravance, Inc.
- Current Assignee: Theravance, Inc.
- Current Assignee Address: US CA South San Francisco
- Agent Jeffrey A. Hagenah; Shelley Eberle
- Main IPC: C07C229/34
- IPC: C07C229/34 ; A61K31/185 ; A61K31/195
Abstract:
In one aspect, the invention relates to compounds having the formula: where R1, R2, R3, a, R4, R5, and R6 are as defined in the specification, or a pharmaceutically acceptable salt thereof. These compounds have neprilysin inhibition activity. In another aspect, the invention relates to pharmaceutical compositions comprising such compounds; methods of using such compounds; and process and intermediates for preparing such compounds.
Public/Granted literature
- US20120308588A1 NEPRILYSIN INHIBITORS Public/Granted day:2012-12-06
Information query
