Apparatus and associate method including a substrate having a first surface; a lid having a second surface; at least one spacer element interposed between the substrate and the lid so as to maintain the first and second surface spaced apart; a partition with a plurality of nanometric size through-openings interposed between the spacer element and the lid defining a first chamber a second chamber fluidically connected together through at least one of the openings; the substrate has at least one first electrode on the first surface and the lid has a second electrode, the first electrode being configured to detect an electric signal associated to the passage of one of said particles through one of the through-openings.