A method of the management for confidential information contained in portable memory media provides recognition by a biometric identification element of the individual who is the proprietor of the information in the proprietor medium; recognition by a biometric identification element of an interlocutor individual, set for inserting and managing the confidential information, who in turn possesses an interlocutor memory medium with identification functions; automatic interfacing and matching between the proprietor medium and the interlocutor medium in terms of user identifications in order to authenticate the access to the stored information on the basis of the preconfigured access permissions; and attachment of a digital signature based on an asymmetric key for the updated/modified information stored on the proprietor medium and on the interlocutor medium.