A system and a method for handling a system failure are disclosed. The method is adapted for an information handling system having a basic input and output system and a micro-controller. The method includes the following steps: sending, via the micro-controller, a signal; checking, via the micro-controller, whether an acknowledgement is received from the basic input and output system responsive to the signal; and scanning, via the micro-controller, a type of a system failure in response to the acknowledgement being not received.