Disclosed herein is a novel method of preparing shoe sole. The method of preparing shoe sole includes irradiating an uncured rubber sheet by laser beam to pattern and vulcanize a portion of the uncured rubber, tailoring the partially patterned vulcanized rubber into a shoe shape, and afterward fully vulcanizing the partially patterned vulcanized rubber sheet to form a shoe sole. An additional step of assembling the upper panel of shoe sole on the partially vulcanized rubber sheet is also performed.