Methods and systems for mapping a physiological signal into clinical guideline parameters are disclosed. A physiological signal having a characteristic that may represent an anomaly is received and mapped to a clinical guideline condition space. Probabilities are determined that the mapped signal with which the anomaly may be associated represents a first clinical guideline condition corresponding to a referral indication or a second clinical guideline condition corresponding to an absence of the referral indication. The determined probability is presented and a referral decision is made responsive to the determined probability that the anomaly is associated with the first clinical guideline condition.