Invention Grant
US08691204B2 Synthetic diblock copolypeptide hydrogels for use in the central nervous system
有权
用于中枢神经系统的合成二嵌段共聚多肽水凝胶
- Patent Title: Synthetic diblock copolypeptide hydrogels for use in the central nervous system
- Patent Title (中): 用于中枢神经系统的合成二嵌段共聚多肽水凝胶
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Application No.: US13201974Application Date: 2010-02-18
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Publication No.: US08691204B2Publication Date: 2014-04-08
- Inventor: Timothy J. Deming , Michael V. Sofroniew , Chu-Ya Yang , BingBing Song , Yan Ao
- Applicant: Timothy J. Deming , Michael V. Sofroniew , Chu-Ya Yang , BingBing Song , Yan Ao
- Applicant Address: US CA Oakland
- Assignee: The Regents of the University of California
- Current Assignee: The Regents of the University of California
- Current Assignee Address: US CA Oakland
- Agency: Venable LLP
- Agent Nancy J. Axelrod; Henry J. Daley
- International Application: PCT/US2010/024603 WO 20100218
- International Announcement: WO2010/096572 WO 20100826
- Main IPC: A61K31/74
- IPC: A61K31/74
Abstract:
This invention relates, e.g., to a composition suitable for administration to the central nervous system (CNS), comprising a block copolypeptide hydrogel, which comprises a biologically active material that is mixed with the hydrogel or that is attached to the polypeptide chain of the hydrogel, wherein the composition is suitable for administration to the CNS. Also disclosed are methods of making and using compositions of the invention as depots or as scaffolds for cell migration, and pharmaceutical compositions and kits for implementing methods of the invention.
Public/Granted literature
- US20120093722A1 SYNTHETIC DIBLOCK COPOLYPEPTIDE HYDROGELS FOR USE IN THE CENTRAL NERVOUS SYSTEM Public/Granted day:2012-04-19
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