Invention Grant
- Patent Title: Stable and soluble antibodies inhibiting TNFα
- Patent Title (中): 稳定和可溶性抗体抑制TNFα
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Application No.: US13708500Application Date: 2012-12-07
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Publication No.: US08691228B2Publication Date: 2014-04-08
- Inventor: Stefan Ewert , Alcide Barberis , David Urech , Adrian Auf Der Maur , Peter Lichtlen
- Applicant: ESBATech, an Alcon Biomedical Research Unit LLC
- Applicant Address: CH
- Assignee: ESBATech, an Alcon Biomedical Research Unit LLC
- Current Assignee: ESBATech, an Alcon Biomedical Research Unit LLC
- Current Assignee Address: CH
- Main IPC: A61K39/00
- IPC: A61K39/00
Abstract:
The present invention relates to particularly stable and soluble scFv antibodies and Fab fragments specific for TNFα, which comprise specific light chain and heavy chain sequences that are optimized for stability, solubility, in vitro and in vivo binding of TNFα, and low immunogenicity. Said antibodies are designed for the diagnosis and/or treatment of TNFα-related disorders. The nucleic acids, vectors and host cells for expression of the recombinant antibodies of the invention, methods for isolating them and the use of said antibodies in medicine are also disclosed.
Public/Granted literature
- US20130171143A1 STABLE AND SOLUBLE ANTIBODIES INHIBITING TNF ALPHA Public/Granted day:2013-07-04
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