Invention Grant
US08691262B2 Method for aligning cells and applying homogenous strain throughout deformable engineered tissue constructs 有权
在整个可变形工程组织构建体中对齐细胞并应用均质菌株的方法

  • Patent Title: Method for aligning cells and applying homogenous strain throughout deformable engineered tissue constructs
  • Patent Title (中): 在整个可变形工程组织构建体中对齐细胞并应用均质菌株的方法
  • Application No.: US13568057
    Application Date: 2012-08-06
  • Publication No.: US08691262B2
    Publication Date: 2014-04-08
  • Inventor: Matthew Thomas Harris
  • Applicant: Matthew Thomas Harris
  • Applicant Address: US AZ Tucson
  • Assignee: Matthew Thomas Harris
  • Current Assignee: Matthew Thomas Harris
  • Current Assignee Address: US AZ Tucson
  • Main IPC: A61F2/02
  • IPC: A61F2/02
Method for aligning cells and applying homogenous strain throughout deformable engineered tissue constructs
Abstract:
A process creates a homogenous sheet of engineered tissue comprised of encapsulated cells and a deformable engineered tissue construct. In the embodiment consisting of a collagen construct with encapsulated cells capable of contracting the matrix, the collagen fibers and encapsulated cells are aligned during the process. An apparatus can deliver controlled homogenous strain and stress to a thin sheet of engineered tissue. This process allows application of dynamic, uniform tensile loading to deformable engineered tissue constructs and creation of an engineered cell-delivery construct with alignment of both fibers and encapsulated cells.
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