Invention Grant
- Patent Title: Anti-CD79B antibodies and immunoconjugates and methods of use
- Patent Title (中): 抗CD79B抗体和免疫缀合物及其使用方法
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Application No.: US13305493Application Date: 2011-11-28
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Publication No.: US08691531B2Publication Date: 2014-04-08
- Inventor: Yvonne Chen , Mark Dennis , David Dornan , Kristi Elkins , Jagath Reddy Junutula , Andrew Polson , Bing Zheng
- Applicant: Yvonne Chen , Mark Dennis , David Dornan , Kristi Elkins , Jagath Reddy Junutula , Andrew Polson , Bing Zheng
- Applicant Address: US CA So. San Francisco
- Assignee: Genentech, Inc.
- Current Assignee: Genentech, Inc.
- Current Assignee Address: US CA So. San Francisco
- Agent Bonny G. Yeung
- Main IPC: C12N15/13
- IPC: C12N15/13 ; C12N15/63 ; C12N15/85 ; C12N5/16
Abstract:
The present invention is directed to compositions of matter comprising nucleic acids encoding a polypeptide comprising the amino acid sequence of SEQ ID NO: 207 or 208, encoding an anti-CD79b antibody comprising the heavy chain variable domain sequence of SEQ ID NO: 207 and the light chain variable domain sequence of SEQ ID NO: 208, or encoding an anti-CD79b antibody having : (i) a variable light chain comprising a HVR-L1 having the sequence of SEQ ID NO: 194, a HVR-L2 having the sequence of SEQ ID NO: 195, and a HVR-L3 having the sequence of SEQ ID NO: 196 and (ii) a variable light chain comprising a HVR-H1 having the sequence of SEQ ID NO: 202, a HVR-H2 having the sequence of SEQ ID NO: 203, and a HVR-H3 having the sequence of SEQ ID NO: 204, and vectors and host cells thereof.
Public/Granted literature
- US20120148600A1 Anti-CD79B Antibodies and Immunoconjugates and Methods of Use Public/Granted day:2012-06-14
Information query
IPC分类:
