Invention Grant
- Patent Title: Single chemical entities and methods for delivery of oligonucleotides
- Patent Title (中): 单一化学实体和递送寡核苷酸的方法
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Application No.: US13639952Application Date: 2011-04-04
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Publication No.: US08691580B2Publication Date: 2014-04-08
- Inventor: Jeffrey G. Aaronson , Stanley F. Barnett , René Bartz , Steven L. Colletti , Vasant R. Jadhav , Aaron A. Momose , Anthony W. Shaw , David M. Tellers , Thomas J. Tucker , Weimin Wang , Yu Yuan
- Applicant: Jeffrey G. Aaronson , Stanley F. Barnett , René Bartz , Steven L. Colletti , Vasant R. Jadhav , Aaron A. Momose , Anthony W. Shaw , David M. Tellers , Thomas J. Tucker , Weimin Wang , Yu Yuan
- Applicant Address: US NJ Rahway
- Assignee: Merck Sharp & Dohme Corp.
- Current Assignee: Merck Sharp & Dohme Corp.
- Current Assignee Address: US NJ Rahway
- Agent Yong Zhao; Laura Ginkel
- International Application: PCT/US2011/031080 WO 20110404
- International Announcement: WO2011/126974 WO 20111013
- Main IPC: C07H21/02
- IPC: C07H21/02

Abstract:
In an embodiment the instant invention discloses a modular composition comprising 1) an oligonucleotide; 2) one or more linkers, which may be the same or different, selected from Table 1, wherein the linkers are attached to the oligonucleotide at any 3′ and/or 5′ end; 3) one or more peptides, which may be the same or different, selected from SEQ ID NOs: 1-59, wherein the peptides are attached to the linkers; and optionally one or more lipids, solubilizing groups and/or targeting ligands attached to the oligonucleotide.
Public/Granted literature
- US20130041133A1 NOVEL SINGLE CHEMICAL ENTITIES AND METHODS FOR DELIVERY OF OLIGONUCLEOTIDES Public/Granted day:2013-02-14
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