Invention Grant
US08691580B2 Single chemical entities and methods for delivery of oligonucleotides 有权
单一化学实体和递送寡核苷酸的方法

Single chemical entities and methods for delivery of oligonucleotides
Abstract:
In an embodiment the instant invention discloses a modular composition comprising 1) an oligonucleotide; 2) one or more linkers, which may be the same or different, selected from Table 1, wherein the linkers are attached to the oligonucleotide at any 3′ and/or 5′ end; 3) one or more peptides, which may be the same or different, selected from SEQ ID NOs: 1-59, wherein the peptides are attached to the linkers; and optionally one or more lipids, solubilizing groups and/or targeting ligands attached to the oligonucleotide.
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