Invention Grant
US08691758B2 Inhibitors of serine proteases, particularly HCV NS3-NS4A protease
失效
丝氨酸蛋白酶抑制剂，特别是HCV NS3-NS4A蛋白酶
- Patent Title: Inhibitors of serine proteases, particularly HCV NS3-NS4A protease
- Patent Title (中): 丝氨酸蛋白酶抑制剂，特别是HCV NS3-NS4A蛋白酶
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Application No.: US11434008Application Date: 2006-05-15
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Publication No.: US08691758B2Publication Date: 2014-04-08
- Inventor: Shawn D. Britt , Kevin M. Cottrell , Robert B. Perni , Janos Pitlik
- Applicant: Shawn D. Britt , Kevin M. Cottrell , Robert B. Perni , Janos Pitlik
- Applicant Address: US MA Boston
- Assignee: Vertex Pharmaceuticals Incorporated
- Current Assignee: Vertex Pharmaceuticals Incorporated
- Current Assignee Address: US MA Boston
- Agent Lisa A. Dixon; Susan C. Kelly
- Main IPC: A61K38/00
- IPC: A61K38/00 ; A01N37/18
Abstract:
The present invention relates to compounds of formula I or formula Ia or pharmaceutically acceptable salts thereof, that inhibit serine protease activity, particularly the activity of hepatitis C virus NS3-NS4A protease. As such, they act by interfering with the life cycle of the hepatitis C virus and are useful as antiviral agents. The invention further relates to pharmaceutically acceptable compositions comprising said compounds either for ex vivo use or for administration to a patient suffering from HCV infection and processes for preparing the compounds. The invention also relates to methods of treating an HCV infection in a patient by administering a pharmaceutical composition comprising a compound of this invention.
Public/Granted literature
- US20060211629A1 Inhibitors of serine proteases, particularly HCV NS3-NS4A protease Public/Granted day:2006-09-21
Information query
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