Invention Grant
- Patent Title: Biglycan and related therapeutics and methods of use
- Patent Title (中): Biglycan及相关疗法及使用方法
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Application No.: US13368968Application Date: 2012-02-08
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Publication No.: US08691766B2Publication Date: 2014-04-08
- Inventor: Justin R. Fallon , Beth A. McKechnie , Michael Rafii , Hilliary Creely , Mark A. Bowe , Alison R. Amenta , Mary Lynn Mercado , Hiroki Hagiwara
- Applicant: Justin R. Fallon , Beth A. McKechnie , Michael Rafii , Hilliary Creely , Mark A. Bowe , Alison R. Amenta , Mary Lynn Mercado , Hiroki Hagiwara
- Applicant Address: US RI Providence
- Assignee: Brown University Research Foundation
- Current Assignee: Brown University Research Foundation
- Current Assignee Address: US RI Providence
- Agency: Ropes & Gray LLP
- Main IPC: A61K38/00
- IPC: A61K38/00 ; A01N37/18 ; G01N33/567 ; G01N33/48 ; G01N33/566

Abstract:
The invention provides compositions and methods for treating, preventing, and diagnosing diseases or conditions associated with an abnormal level or activity of biglycan; disorders associated with an unstable cytoplasmic membrane, due, e.g., to an unstable dystrophin associated protein complex (DAPC); disorders associated with abnormal synapses or neuromuscular junctions, including those resulting from an abnormal MuSK activation or acetylcholine receptor (AChR) aggregation. Example of diseases include muscular dystrophies, such as Duchenne's Muscular Dystrophy, Becker's Muscular Dystrophy, neuromuscular disorders and neurological disorders.
Public/Granted literature
- US20120245095A1 BIGLYCAN AND RELATED THERAPEUTICS AND METHODS OF USE Public/Granted day:2012-09-27
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