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US08691770B2 Method for processing microbiologically produced cyclic oligopeptides 失效
微生物产生的环状寡肽的加工方法

Method for processing microbiologically produced cyclic oligopeptides
Abstract:
The present invention relates to a method for processing microbiologically produced, non-polar, cyclic oligopeptides comprising the step of a) extracting the entire fermentation broth incident to the microbiological production process using a liquid extractant that contains ether and is immiscible with water, wherein the amount of extractant is sufficient to form a two-phase system together with the total fermentation broth, and novel solvates of cyclosporin A and methyl-t-butyl ether.
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