Invention Grant
- Patent Title: Method for processing microbiologically produced cyclic oligopeptides
- Patent Title (中): 微生物产生的环状寡肽的加工方法
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Application No.: US13055715Application Date: 2009-07-29
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Publication No.: US08691770B2Publication Date: 2014-04-08
- Inventor: Stephan Bertel
- Applicant: Stephan Bertel
- Applicant Address: CH Basel
- Assignee: Sandoz AG
- Current Assignee: Sandoz AG
- Current Assignee Address: CH Basel
- Agency: Manelli Selter PLLC
- Agent Jeffrey S. Melcher
- Priority: EP08161348 20080729
- International Application: PCT/EP2009/059826 WO 20090729
- International Announcement: WO2010/012786 WO 20100204
- Main IPC: A61K38/13
- IPC: A61K38/13 ; A61K38/12 ; C07K5/00 ; C07K7/00 ; C07K16/00 ; C07K17/00 ; C07K1/14 ; C07K7/64

Abstract:
The present invention relates to a method for processing microbiologically produced, non-polar, cyclic oligopeptides comprising the step of a) extracting the entire fermentation broth incident to the microbiological production process using a liquid extractant that contains ether and is immiscible with water, wherein the amount of extractant is sufficient to form a two-phase system together with the total fermentation broth, and novel solvates of cyclosporin A and methyl-t-butyl ether.
Public/Granted literature
- US20110124575A1 METHOD FOR PROCESSING MICROBIOLOGICALLY PRODUCED CYCLIC OLIGOPEPTIDES Public/Granted day:2011-05-26
Information query
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