Invention Grant
- Patent Title: Amino tetrahydro-pyridopyrimidine PDE10 inhibitors
- Patent Title (中): 氨基四氢吡啶并嘧啶PDE10抑制剂
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Application No.: US13389270Application Date: 2010-08-05
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Publication No.: US08691827B2Publication Date: 2014-04-08
- Inventor: Michael J. Breslin , Paul J. Coleman , Christopher D. Cox , Izzat T. Raheem , John D. Schreier
- Applicant: Michael J. Breslin , Paul J. Coleman , Christopher D. Cox , Izzat T. Raheem , John D. Schreier
- Applicant Address: US NJ Rahway
- Assignee: Merck Sharp & Dohme Corp.
- Current Assignee: Merck Sharp & Dohme Corp.
- Current Assignee Address: US NJ Rahway
- Agent Sylvia A. Ayler; John C. Todaro
- International Application: PCT/US2010/044482 WO 20100805
- International Announcement: WO2011/022213 WO 20110224
- Main IPC: A01N43/90
- IPC: A01N43/90 ; A61K31/519 ; C07D487/00
Abstract:
The present invention is directed to amino tetrahydro-pyridopyrimidine compounds which are useful as therapeutic agents for the treatment of central nervous system disorders associated with phosphodiesterase 10 (PDE10). The present invention also relates to the use of such compounds for treating neurological and psychiatric disorders, such as schizophrenia, psychosis or Huntington's disease, and those associated with striatal hypofunction or basal ganglia dysfunction.
Public/Granted literature
- US20120136012A1 AMINO TETRAHYDRO-PYRIDOPYRIMIDINE PDE10 INHIBITORS Public/Granted day:2012-05-31
Information query
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