Invention Grant
US08691849B2 3-azabicyclo[3.1.0]hexyl derivatives as modulators of metabotropic glutamate receptors
失效
3-氮杂双环[3.1.0]己基衍生物作为代谢型谷氨酸受体的调节剂
![3-azabicyclo[3.1.0]hexyl derivatives as modulators of metabotropic glutamate receptors](/docs/US/2014-04-08/US08691849B2/abs.jpg.600x600.jpg)
- Patent Title: 3-azabicyclo[3.1.0]hexyl derivatives as modulators of metabotropic glutamate receptors
- Patent Title (中): 3-氮杂双环[3.1.0]己基衍生物作为代谢型谷氨酸受体的调节剂
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Application No.: US13061183Application Date: 2009-09-01
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Publication No.: US08691849B2Publication Date: 2014-04-08
- Inventor: Jose Maria Cid-Nunez , Andres Avelino Trabanco-Suarez
- Applicant: Jose Maria Cid-Nunez , Andres Avelino Trabanco-Suarez
- Applicant Address: US NJ Titusville CH Geneva
- Assignee: Janssen Pharmaceuticals, Inc.,Addex Pharma SA
- Current Assignee: Janssen Pharmaceuticals, Inc.,Addex Pharma SA
- Current Assignee Address: US NJ Titusville CH Geneva
- Agency: Baker & Hostetler LLP
- Priority: EP08163517 20080902
- International Application: PCT/EP2009/006326 WO 20090901
- International Announcement: WO2010/025890 WO 20100311
- Main IPC: A61K31/4439
- IPC: A61K31/4439 ; A61P25/22 ; A61P25/18 ; A61P25/30 ; A61P25/00 ; A61P25/24 ; A61P25/06 ; A61P25/08 ; A61P25/28 ; A61P9/10 ; C07D401/04 ; A61P3/00
![3-azabicyclo[3.1.0]hexyl derivatives as modulators of metabotropic glutamate receptors](/abs-image/US/2014/04/08/US08691849B2/abs.jpg.150x150.jpg)
Abstract:
The present invention relates to novel compounds, in particular novel pyridinone derivatives according to Formula (I) wherein all radicals are as defined in the application and claims. The compounds according to the invention are positive allosteric modulators of metabotropic receptors—subtype 2 (“mGluR2”) which are useful for the treatment or prevention of neurological and psychiatric disorders associated with glutamate dysfunction and diseases in which the mGluR2 subtype of metabotropic receptors is involved. In particular, such diseases are central nervous system disorders selected from the group of anxiety, schizophrenia, migraine, depression, and epilepsy. The invention is also directed to pharmaceutical compositions and processes to prepare such compounds and compositions, as well as to the use of such compounds for the prevention and treatment of such diseases in which mGluR2 is involved.
Public/Granted literature
- US20110306642A1 3-AZABICYCLO[3.1.0]HEXYL DERIVATIVES AS MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS Public/Granted day:2011-12-15
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