Invention Grant
- Patent Title: EP4 agonist
- Patent Title (中): EP4激动剂
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Application No.: US13675530Application Date: 2012-11-13
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Publication No.: US08691857B2Publication Date: 2014-04-08
- Inventor: Takahiko Murata , Masahiro Amakawa , Shin Teradaira , Yasushi Matsumura , Katsuhiko Konishi
- Applicant: Asahi Glass Company, Limited , Kaken Pharmaceutical Co., Ltd.
- Applicant Address: JP Tokyo JP Tokyo
- Assignee: Asahi Glass Company, Ltd.,Kaken Pharmaceutical Co., Ltd.
- Current Assignee: Asahi Glass Company, Ltd.,Kaken Pharmaceutical Co., Ltd.
- Current Assignee Address: JP Tokyo JP Tokyo
- Agency: Leydig, Voit & Mayer, Ltd.
- Priority: JP2008-232133 20080910; JP2009-168193 20090716
- Main IPC: C07D405/06
- IPC: C07D405/06 ; A61K31/4025

Abstract:
Provided is a compound represented by the formula (1): wherein R1 and R2 are each independently a hydrogen atom or a straight chain alkyl group having a carbon number of 1-3, R3 is a hydrogen atom, an alkyl group having a carbon number of 1-4, an alkoxyalkyl group, an aryl group, a halogen atom or a haloalkyl group, or a pharmaceutically acceptable salt thereof, which has, unlike known PGI2 analogs, a selective EP4 agonist action, and a medicament containing the compound, which is useful for the prophylaxis and/or treatment of immune diseases, diseases of the digestive tract, cardiovascular diseases, cardiac diseases, respiratory diseases, neurological diseases, ophthalmic diseases, renal diseases, hepatic diseases, bone diseases, skin diseases and the like.
Public/Granted literature
- US20130072530A1 NOVEL EP4 AGONIST Public/Granted day:2013-03-21
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