Invention Grant
- Patent Title: Solid pharmaceutical dosage form
- Patent Title (中): 固体药物剂型
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Application No.: US13674799Application Date: 2012-11-12
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Publication No.: US08691878B2Publication Date: 2014-04-08
- Inventor: Jeorg Rosenberg , Ulrich Reinhold , Bernd Liepold , Gunther Berndl , Joerg Breitenbach , Laman Alani , Soumojeet Ghosh
- Applicant: AbbVie Inc.
- Applicant Address: US IL North Chicago
- Assignee: AbbVie Inc.
- Current Assignee: AbbVie Inc.
- Current Assignee Address: US IL North Chicago
- Agent Bradley E. Davis
- Main IPC: A61K8/72
- IPC: A61K8/72 ; A61K9/20 ; A61K9/48 ; A61K31/425

Abstract:
A solid pharmaceutical dosage form providing improved oral bioavailability is disclosed for inhibitors of HIV protease. In particular, the dosage form comprises a solid dispersion of at least one HIV protease inhibitor and at least one pharmaceutically acceptable water-soluble polymer and at least one pharmaceutically acceptable surfactant, said pharmaceutically acceptable water-soluble polymer having a Tg of at least about 50° C. Preferably, the pharmaceutically acceptable surfactant has an HLB value of from about 4 to about 10.
Public/Granted literature
- US20130072508A1 SOLID PHARMACEUTICAL DOSAGE FORM Public/Granted day:2013-03-21
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