Invention Grant
US08691882B2 Organic-inorganic hybrid scaffolds with surface-immobilized nano-hydroxyapatite and preparation method thereof
有权
具有表面固定化纳米羟基磷灰石的有机 - 无机杂化支架及其制备方法
- Patent Title: Organic-inorganic hybrid scaffolds with surface-immobilized nano-hydroxyapatite and preparation method thereof
- Patent Title (中): 具有表面固定化纳米羟基磷灰石的有机 - 无机杂化支架及其制备方法
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Application No.: US12635615Application Date: 2009-12-10
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Publication No.: US08691882B2Publication Date: 2014-04-08
- Inventor: Sang Cheon Lee , Jeong Ho Chang , Jin Hyung Lee , Kyung Ja Kim , Sung Eun Kim , Ho Chan Hwang , Ke-Won Kang , Seog-Jin Seo , Jin-Young Kim
- Applicant: Sang Cheon Lee , Jeong Ho Chang , Jin Hyung Lee , Kyung Ja Kim , Sung Eun Kim , Ho Chan Hwang , Ke-Won Kang , Seog-Jin Seo , Jin-Young Kim
- Applicant Address: KR Seoul
- Assignee: Korea Institute of Ceramic Engineering & Technology
- Current Assignee: Korea Institute of Ceramic Engineering & Technology
- Current Assignee Address: KR Seoul
- Agency: Knobbe, Martens, Olson & Bear, LLP
- Priority: KR10-2007-0118713 20071120
- Main IPC: C07K14/78
- IPC: C07K14/78 ; C08J9/00 ; C08G63/06
Abstract:
Provided are an organic-inorganic hybrid scaffold with surface-immobilized nano-hydroxyapatite, and a method for the fabrication thereof. The scaffold is fabricated by reacting an acid group present on a surface of nano-hydroxyapatite with a primary amine present on a surface of a polymer support in the presence of EDC (1-ethyl-3-dimethylaminopropyl carbodiimide) to immobilize nano-hydroxyapatite onto the surface of the polymer support. The surface of nano-hydroxyapatite is previously grafted with poly(ethylene glycol methacrylate phosphate) (PolyEGMP) having phosphonic acid functionality or with a polymer having carboxylic acid functionality.
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