Invention Grant
US08691971B2 Self delivering bio-labile phosphate protected pro-oligos for oligonucleotide based therapeutics and mediating RNA interference
有权
自我传递生物不稳定磷酸盐保护的寡核苷酸为基础的治疗和介导RNA干扰
- Patent Title: Self delivering bio-labile phosphate protected pro-oligos for oligonucleotide based therapeutics and mediating RNA interference
- Patent Title (中): 自我传递生物不稳定磷酸盐保护的寡核苷酸为基础的治疗和介导RNA干扰
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Application No.: US13120409Application Date: 2009-09-23
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Publication No.: US08691971B2Publication Date: 2014-04-08
- Inventor: Scott G. Petersen
- Applicant: Scott G. Petersen
- Agent Timothy M. Brown, Esq.
- International Application: PCT/US2009/058064 WO 20090923
- International Announcement: WO2010/039543 WO 20100408
- Main IPC: C07H19/04
- IPC: C07H19/04 ; C07H21/02 ; C12N15/11 ; C12N5/071 ; A61K31/70 ; A61K31/7088
Abstract:
Disclosed herein are compositions and methods for generating ribo-nucleic neutral (RNN) or deoxyribo-nucleic-neutral (DNN) polynucleotides with reduced anionic charge, for improved intracellular delivery. Also disclosed herein are methods of using RNN and DNN compositions.
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